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Bacterial De Novo Sequencing Analysis

Bacterial De Novo Sequencing Analysis Online Inquiry

CD Genomics provides bacterial de novo sequencing data analysis. Using bioinformatics to explore the whole genome sequence map of bacteria in one step, our unique data analysis skills and advanced software tools can meet our customers' personalized data analysis needs and provide you with easy-to-interpret data analysis reports.

Bacterial De Novo Sequencing Analysis

Bacterial genome de novo sequencing is a method to obtain the whole genome sequence of bacteria through genome sequencing and assembly without reference genome, and carrying out structural and functional research on it. After sequencing these bacteria, a series of follow-up studies of the species will be conducted, so as to better understand and control the characteristics and physiological processes of the strain. Bacterial de novo sequencing has replaced the traditional methods for studying the genetic mechanism and key functional genes of bacterial evolution.

Bioinformatic analysis of bacterial genome de novo sequencing is based on assembly, to perform genome composition analysis, functional annotation, single gene or gene interaction, expression regulation and other functions. In addition, important genes and proteins can be predicted to understand bacterial function and possible related mechanisms.

Whole-genome phylogenetic tree of ExPEC E. coli isolates. Fig 1. Whole-genome phylogenetic tree of ExPEC E. coli isolates. (Salipante S J, et al.2014.)

Application Field

Pathogenic bacteria pathogenicity and disease prevention and treatment research.

Identification of disease-related genes.

Vaccine development and research.

Development of new antibiotics.

Evolutionary analysis.

Advantages of CD Genomics

Thoroughly planned analysis process, fast delivery and short cycle time.

Rich and in-depth analysis content.

Personalized analysis and chart making.

Rich experience in bacterial genome analysis.

CD Genomics Data Analysis Pipeline

CD Genomics bacterial de novo sequencing data analysis pipeline - CD Genomics.

Bioinformatics Analysis Content

CD Genomics processes bacterial genomic data generated by next-generation sequencing or third-generation sequencing, and can handle data of different depths or sequencing strategies. We will adopt different bioinformatic analysis strategies according to different types of raw data.


Data preprocessing

Sequencing data statistics

Remove adapter sequence and low-quality sequence

Genome assembly

Genome assembly.

Evaluation of assembly results

Genome structure research

Coding/non-coding gene prediction

Repeat sequence analysis

Gene island prediction

Prophage prediction

CRISPR prediction

Gene function annotation

Functional database comments (such as GO, COG, KEGG, SwissProt,)

Genomic methylation modification analysis

Pathogenic research
Correlation Analysis

Secretory system effector protein prediction

Pathogen-host interaction analysis

Secreted protein analysis

Gene cluster analysis of secondary metabolites

Annotation of virulence factors and drug resistance genes of bacterial pathogens

If you have other requirements for bacterial genome de novo sequencing bioinformatic analysis, for example, collinearity analysis between genomes, mutation detection between genomes, Core-pan gene analysis, and evolutionary tree construction, we will provide the right biological information analysis strategy according to your needs. For analysis content, price, cycle, if you have any questions, please use online inquiry.

How It Works

CD Genomics is a professional bioinformatics service provider with years of experience in NGS and long read sequencing (PacBio SMRT and Oxford Nanopore platforms) data analysis, integrated analysis services, database construction and other bioinformatics solutions.

How It Works

CD Genomics provides general and customized analyses of bacterial genome de novo sequencing data. With experienced teams of scientists, we provide fast turnaround, high-quality data reports at competitive prices for worldwide customers. Customers can contact our scientists directly to receive prompt responses. If you are interested in our services, please contact us for more detailed information.

Reference

  1. Salipante S J, et al. Large-scale genomic sequencing of extraintestinal pathogenic Escherichia coli strains. Genome Research, 2014, 25(1).
* For Research Use Only. Not for use in diagnostic procedures.
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