Whole Genome Resequencing Analysis

CD Genomics provides whole genome resequencing data analysis service. We use bioinformatics to help you quickly locate mutations and explore genetic variations at the DNA level. Our unique skills in data analysis can meet customers' personalized data analysis needs and provide you with comprehensive data analysis results.

Introduction to Whole Genome Resequencing Analysis

Whole Genome Resequencing makes use of high-throughput sequencing method to sequence the whole genome of individuals or groups to find sequence or structural variation and other information. Whole Genome Resequencing is only applied on the species with known reference genome sequence. The sequencing is carried out on different individuals (such as patients and normal individuals) or different tissues of an individual (such as diseased tissues and normal tissues). Differences between individuals or between tissues and cells can be found at the overall level. After the alignment of each sample’s sequenced data to the reference genome sequence, we can find a large number of variation information such as single nucleotide variants (SNV), insertion and deletion (InDel), structural variation (SV) and copy number variation (CNV), so as to find the pathogenic genes and mutations of the disease, analyze the pathogenesis of the disease, population genetic mechanism and obtain population genetic characteristics.

Fig.1 copy number variations and structure variation. (Shu Y et al., 2018)

We Can Help Our Clients With

Whole genome resequencing analysis can be used for but is not limited to the following research:

CD Genomics Data Analysis Workflow

What We Offer

• Data quality control, remove joint contamination and low-quality data
• Align to reference genome sequence, make statistics of sequencing depth and coverage
• SNP / InDel / SV / CNV detection, annotation, effect prediction and statistics
• Circos diagram display of genome variation
• GO / KEGG classification and enrichment analysis of the interested genes

In addition, we can tailor the content of whole-genome biological information analysis according to your specific project needs.

How It Works

CD Genomics is a professional bioinformatics service provider with years of experience in NGS and long read sequencing (PacBio SMRT and Oxford Nanopore platforms) data analysis, integrated analysis services, database construction and other bioinformatics solutions.

CD Genomics provides general analysis and customized analysis of whole genome sequencing data analysis. Experienced teams of scientists, researchers, and technicians, we provide fast turnaround, high-quality data reports at competitive prices for worldwide customers. Customers can contact our employees directly and we will respond promptly. If you are interested in our services, please contact us for more detailed information.

Reference

1. Teixeira V H ; et al. Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions. Nature Medicine, 2019.