CD Genomics can help customers detect the proportion and variation of differentially expressed proteins in functions, pathways, structural domains, and complexes using protein structural domain enrichment analysis.
Introduction of Domain Enrichment Service
Protein structural domains, as functional units, manifest different structural domains with specific functions and play an important role in the functional modules of organisms, and the study of protein structural domains implies great significance to reveal the complex and diverse functional modules in organisms. Key proteins, as conserved proteins in protein interactions, are difficult to be changed by the external environment. The analysis of the enrichment level of protein structural domains can identify important features of key proteins.
Figure 1. Gene Ontology (GO) functional and protein domain enrichment analysis of all the high-risk mutant genes of the F. nucleatum-positive samples. (Li Z, et al., 2021)
Application Field
Domain enrichment services can be used for but are not limited to the following research:
- For exploring pathogenic mechanisms.
- For the exploration of potential therapeutic targets.
- Used to reveal population genetic variation.
Deliverables
- Protein structural domain enrichment bar graph.
- Protein structural domain enrichment histogram.
Domain Enrichment Service Content
There is a close relationship between protein structure and function. For example, antimicrobial peptide structural domain enrichment results showed enrichment of the bilayer sandwich of CATH, knottin of SCOP, and cluster1 structural domain of TM, which also have antifungal activity. We provide structural domain enrichment analysis based on three structural classification methods, SCOP, CATH, and TM.
We used a hypergeometric distribution test-based approach to perform enrichment and deletion significance analysis of specific feature structure domains.
We are able to perform functional enrichment of single structural domain proteins and multiple structures domain proteins, providing guidance for interaction analysis of host proteins with enriched structural domains.
We are able to use domain enrichment services to help our customers achieve high throughput data analysis in genomics and proteomics. For questions about analysis content, project cycle, and pricing, please click online inquiry.
How It Works
CD Genomics is a professional bioinformatics service provider with years of experience in NGS and long-read sequencing (PacBio SMRT and Oxford Nanopore platforms) data, proteomics and metabolomics data analysis, integrated analysis services, database construction, and other bioinformatics solutions.
CD Genomics has professional bioinformatics experts who have successfully provided domain enrichment services to researchers in many different fields. Our professional skills and enthusiasm will provide you with high-quality analysis services. If you are interested in our services, please contact us for more details.
Reference
- Li Z, et al. Fusobacterium nucleatum predicts a high risk of metastasis for esophageal squamous cell carcinoma. BMC Microbiol. 2021 Oct 30; 21(1): 301.
