The CRISPR-Cas system is a prokaryotic immune system that confers resistance to foreign genetic elements. In recent years, the CRISPR-Cas system has also been engineered to facilitate target gene editing in eukaryotic genomes. The CRISPR screen is an essential molecular target technique of high-throughput screening. Bioinformatics plays an essential role in the analysis of CRISPR system-based studies.
The CRISPR-Cas system is an RNA-directed endonuclease for genome engineering. Advances in CRISPR screening technology have made it possible to systematically and reliably determine the nature of genes under a variety of conditions. The CRISPR-Cas9 gene targeting system allows scientists to modify parts of the genome by removing, adding, or altering parts of an organism's DNA sequence. It is currently the simplest, most flexible, accurate, and effective genetic manipulation technique with many possible applications. To maximize genome editing, CRISPR-Cas9 has also been adapted and pioneered the generation of targeted mutations.
The high-quality gene necessity profile of CRISPR allows for a better comparison between importance prediction methods and better classification of various features of essential genes. These features not only allow for a better understanding of CRISPR screening data but also help prioritize CRISPR screening leads.
◎ Complex disease research.
◎ Animal and plant genomics research.
◎ Metagenomic research.
◎ Pharmacogenomics research.
◎ Nutrigenomics research.
◎ Personalized medication.
◎ Genetic testing.
◎ Research on special characters of animals and plants.
◎ Genome-wide association analysis.
◎ eQTL analysis.
1. Statistics of sequencing results.
2. Data quality control statistics.
3. Map to reference genome or de novo genome assembly.
4. SNP and CNV detection and annotation.
5. sgRNA Abundance Analysis.
6. Differential analysis of abundances of sgRNAs.
7. Validation of CRISPR Libraries.
8. Analysis of predicted off-target loci.
9. Functional annotation of genes in regions related to target traits.
CD Genomics is a professional bioinformatics service provider with years of experience in NGS and long read sequencing (PacBio SMRT and Oxford Nanopore platforms) data analysis, integrated analysis services, database construction and other bioinformatics solutions.
CD Genomics, as one of the most competitive service providers in sequencing and data analysis, we use CRISPR technologies and advanced bioinformatics to help you explore the genetic information and decipher the essence of life. Our skills and experience in data analysis can meet customers' personalized data analysis needs. We provide high-quality data analysis services and generate high-quality analysis reports. If you are interested in our services, please contact us for more detailed information. We have a professional technical support team, online 24 hours, ready to serve you at any time.