As one of the providers of viral metagenomics analysis, CD Genomics uses bioinformatics to help you study viruses in environmental and biological samples, aiming to increase understanding of the diversity and function of the viral world. Our high-quality data analysis platform will be used to generate high-quality analysis results in a fast analysis cycle.
Research Advances in Viral Metagenomics Analysis
Viruses are the most numerous biological entities in the biosphere and have the ability to infect bacteria, archaea and eukaryotes. Many outbreaks of such diseases are caused by viruses. Viruses represent a largely unexplored genetic diversity and have an important role in the genomic plasticity of their hosts. In addition, they play an important role in the dynamics of microbial populations. In recent years, metagenomics approaches have become increasingly popular in environmental virome studies, offering the possibility to expand our knowledge of viral diversity and its functional characterization. High-throughput next-generation sequencing technologies based on metagenomicss may be the solution to detect new infectious genomes and to correctly diagnose certain diseases. Bioinformatics analysis is the most important and increasingly demanding part of today's viral macrogenomics analysis.
Fig. 1. Bioinformatics pipeline for viral metagenomics. (Bzhalava D, et al, 2013)
Application Field
Our viral metagenomics analysis can be used for but not limited to the following research:
Human virome studies: our viral metagenomics analyses help to identify and characterize the viral components of the human virome. By studying the viral communities in the human body, we help you gain insight into the diversity of human-associated viruses and their potential role in health and disease.
Environmental virology: CD Genomics' expertise in viral metagenomics analysis contributes to environmental virology studies, providing insight into the role of viruses in shaping ecosystems and their potential interactions with other organisms.
Agricultural virology: our viral metagenomics analysis services enable analysis of viral communities in plants, allowing researchers to monitor the presence of known and novel viral pathogens, study viral diversity, and develop effective disease management strategies.
CD Genomics Data Analysis Pipeline:
CD Genomics is committed to providing state-of-the-art services for viral metagenomics analysis. With expertise in genomics and bioinformatics, we offer a comprehensive range of customized services to meet the specific needs of researchers in this field. Our services cover the entire workflow of viral metagenomics analysis from pre-processing to data analysis.
(1) Data pre-processing
Our raw sequencing data obtained from high-throughput sequencing platforms such as Illumina or Oxford Nanopore undergoes an initial pre-processing step. Quality filtering is performed to eliminate reads with low base quality scores, ensuring that only high quality reads are used for downstream analysis.
(2) Quality control
We provide viral metagenomics data quality control measures to assess overall data quality and identify any potential problems or biases. The assessment includes metrics such as sequence length distribution, per-base sequence quality, and repeat levels.
(3) Read Mapping
We compare or map processed reads to a reference virus database or reference genome to identify viral sequences.
(4) Assembly
We provide de novo assembly aimed at reconstructing the viral genome from sequenced reads to get a more comprehensive understanding of the viral diversity in the sample.
(5) Taxonomic classification
Our researchers can perform taxonomic classification using a variety of methods, including comparison-based approaches, k-mer analysis, or machine learning algorithms. Taxonomic classification provides information about the identified virus species by comparing virus sequences with known virus genomes or reference databases.
(6) Functional annotation
We provide functional annotations to identify putative functions of viral genes or gene products, predict viral protein-coding regions and compare them to existing protein databases to infer their potential functions.
(7) Data interpretation and visualization
The results obtained from bioinformatics analysis are interpreted and summarized to generate comprehensive reports.
Viral Metagenomics Analysis Content:
| Identify Virus Species and Relative Abundance
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Allows identification and quantification of viral reads, enabling determination of the relative abundance of viral species in a sample. |
| Taxonomic Classification |
Further analysis of assembled overlapping groups or mapped reads to determine the taxonomic origin of viral sequences. |
| Viral Function Annotation |
Provides insight into the biological activity and interactions of viral genes, elucidating their role in viral infection and host interactions. |
How It Works
CD Genomics is a high-tech company specializing in multiomic data analysis. We provide services such as project design, data analysis, and database construction. With a focus on developing breakthrough products and services, we are a pioneer in the biotechnology industry, serving researchers and partners worldwide.
CD Genomics offers a range of services tailored to viral metagenomics analysis to help clients fully explore viral communities in diverse environments. We aim to advance the field of virology and its applications in a variety of disciplines. If you are interested in our services, please contact us for more detailed information.
Reference
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Bzhalava D, Dillner J. Bioinformatics for viral metagenomics[J]. J Data Mining Genomics Proteomics, 2013, 4(3): 2153-0602.1000134.
