CD Genomics can help customers annotate and analyze differentially expressed genes through functional annotation services to uncover relevant biological significance, thus providing theories for basic research on diseases, pathogenesis, drug discovery, etc.
Functional annotation is the process of attaching biological information to a gene sequence or protein sequence. Broadly speaking, annotation can be divided into two steps, which are homology annotation and functional classification. Homology annotation compares a sequence that needs further study with a database of known proteins and annotates the function of a homologous gene within the database as the function of that sequence.
Genome function annotation is the main research goal of functional genomics, which includes the application of bioinformatics methods to annotate the biological functions of all coding products of the genome in a high-throughput manner.
Figure 1. Generalized functional annotation workflow. (Saha S, et al., 2021)
Functional annotation services can be used for but are not limited to the following research:
Gene function annotation mainly includes the prediction of structural domains in genes, protein functions, and the biological pathways in which they are located. The sequence similarity matching score method is commonly used to annotate gene functions. We are able to provide the following functional annotation services, including but not limited to:
|Functional annotation of advisory sequences using maximally similar homologous genes.|
|Using MOTIF. Modules are usually functionally relevant and conserved sequences.|
|Cluster of orthologous group.|
|NCBI: Official Non-Redundant Protein Database||Swiss-Prot: High-quality protein database|
|KEGG: Metabolic Pathway Annotation Database||GO: Gene ontology annotation database|
|Pfam: Classification system for protein structural domain annotation||KOG: Clusters of orthologous groups for eukaryotic complete genomes|
We are able to use functional annotation services to help our customers achieve high throughput data analysis in multi-omics data. For questions about analysis content, project cycle, and pricing, please click online inquiry.
CD Genomics is a professional bioinformatics service provider with years of experience in NGS and long-read sequencing (PacBio SMRT and Oxford Nanopore platforms) data, proteomics and metabolomics data analysis, integrated analysis services, database construction, and other bioinformatics solutions.
CD Genomics has professional bioinformatics experts who have successfully provided functional annotation services to researchers in many different fields. Our professional skills and enthusiasm will provide you with high-quality analysis services. If you are interested in our services, please contact us for more details.