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Targeted Metabolomics Analysis

Targeted Metabolomics Analysis

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What Do We Analyze?

CD Genomics is a global biological information analysis service provider. We provide targeted metabolomics data analysis services, helping to detect and analyze target metabolites quickly and accurately. Once we receive the data from you, we will start the data analysis and provide you the most complete and easy-to-interpret analysis result report.

Introduction to Targeted Metabolomics Analysis

The research of metabolomics is mainly divided into non-targeted metabolomics and targeted metabolomics. Non-targeted metabolomics mainly detects the relative content of metabolites in samples. On the other hand, targeted metabolomics uses standard products as a reference to conduct targeted and specific detection and analysis of specific metabolite groups, which can verify candidate biomarkers and analyze known target compounds.

By analyzing mass spectrometry data, it is possible to quantitatively study the multiple dynamic responses of living organisms to external stimuli, physiological and pathological changes and gene mutations in the level of metabolites in the body. Targeted metabolome analysis is through the enrichment and accurate quantitative qualitative analysis of a specific metabolite in blood, urine or other body fluids and tissues. On the one hand, it can be combined with other experimental data to reveal the relevant molecular biological mechanism of action. On the other hand, it can also provide strong support for the in-depth research, development and utilization of subsequent metabolic molecular markers. The detection and analysis of different metabolites can be used for pharmacokinetic research, clinical diagnosis, inspection of illicit drugs, food and cosmetics and other industrial quality control, environmental testing, pesticide residues, small molecule biomarker verification, and other related research.

A high-fiber diet selectively promotes a group of short-chain fatty acid producers as the major active producers. Fig 1.A high-fiber diet selectively promotes a group of short-chain fatty acid producers as the major active producers. (Zhao L, et al 2018)

  • Data analysis
  • Bile acid
  • Amino acid
  • Neurotransmitters
  • Fatty
  • Plant hormone
  • Vitamin

What we can do

CD Genomics provides identification analysis of different small molecule substances and joint analysis services between metabolome and different omics. In addition to general data analysis, we can also provide customized data analysis, chart production services, and one-stop solutions for your research.

Our Advantages

Quantitative information of multiple small molecules can be analyzed simultaneously using mass spectrum data.

Strict data quality control and standardized analysis process to obtain reproducible data.

Multi-omics joint analysis: providing joint analysis services from genomics, transcriptomics, proteomics, to metabolomics, in-depth analysis of biological phenomena.

Personalized data analysis and charts that can be directly used for publication.

Professional bioinformatic analysis team.

CD Genomics Data Analysis Pipeline

CD Genomics targeted metabolomics data analysis pipeline - CD Genomics.

Bioinformatics Analysis Content

CD Genomics provides targeted metabolic compound detection and analysis, which can perform relative quantitative or absolute quantitative analysis according to the actual needs of customers.

Standard information analysis Draw standard curve
Data quality control
Results of quantitative analysis of target small molecules
Data distribution
Comparative group analysis
Customized information analysis Phenotypic analysis, only applicable to some small molecule quantitative analysis products
Multi-omics joint analysis
Other customized information analysis

For targeted metabolomics data analysis,the content of customized information analysis services can be negotiated and determined based on the needs of customers, including distinguishing isomers. For analysis content, price, cycle, if you have any questions, please click online inquiry.

CD Genomics provides general analysis and customized analysis of targeted metabolomics data for different types of small molecular LC-MS/MS data. In addition to the identification and analysis of small molecular metabolites such as bile acids, amino acids, neurotransmitters, fatty acids, plant hormones, vitamins, we can also perform data analysis on other small molecular metabolites such as flavonoids, energy metabolism, arachidonic acid, etc. We will provide you with satisfactory data analysis services. If you are interested in our services, please feel free to get in touch for more detailed information.

Reference

  1. Zhao L, et al. Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes[J]. Science, 2018, 359(6380):1151-1156.

Importance of Bile Acid

Targeted Metabolomics Analysis Bile acids are hydroxy derivatives of a class of 24-carbon cholanoic acid synthesized from cholesterol. It is a general term for a large class of cholanoic acid present in bile, in the form of sodium or potassium salt. It is an important metabolite in the hepatoenteric circulation. Bile acids have a variety of important biological functions, such as promoting the digestion and absorption of fat-soluble substances, regulating the body's bile acid metabolism, lipid metabolism, sugar metabolism, and participating in immune processes. It exists in human and animal bile, blood, and feces, and is related to hepatobiliary diseases and gastrointestinal diseases. It is one of the focuses of intestinal microbial research in recent years.

Application Field

Pathological mechanism research, which can be applied to the pathological mechanism research of hepatobiliary diseases, gastrointestinal diseases, and metabolic diseases.

Drug development and treatment effect monitoring.

Auxiliary diagnosis of diseases, assist in the diagnosis of liver and gallbladder diseases, gastrointestinal diseases, genetic metabolic defects diseases, and judge the progress of the disease.

Analytical Substance

Substance name Abbreviation
Cholic acid CA
Glycocholic acid GCA
Taurocholic acid TCA
Chenodeoxycholic acid CDCA
Glycochenodeoxycholic acid GCDCA
Taurochenodeoxycholic acid TCDCA
Deoxycholic acid DCA
Lithocholic acid LCA
...

Importance of Amino Acid

Amino acid is a general term for a class of organic compounds containing amino and carboxyl groups. The basic unit of biologically functional macromolecular protein is the basic material that constitutes the protein required for animal nutrition and the most important functional material for life activities. Amino acids participate in biological processes such as energy metabolism, immune regulation, endocrine regulation, and signal transduction. It is closely related to research on tumors, cardiovascular diseases, metabolic diseases, nervous system diseases, etc., and related to the growth and development, stress resistance, and maturation process of plants.

Application Field

Tumor research

Cardiovascular diseases

Metabolic disease

Nervous system disease

Plant research

Analytical Substance

Substance name Abbreviation
Alanine Ala
Arginine Arg
Cysteine Cys
Aspartic acid Asp
Glutamic acid Glu
Histidine His
Isoleucine Ile
Glycine Gly
Asparagine Asn
Leucine Leu
Lysine Lys
Methionine Met
Phenylalanine Phe
Proline Pro
Alanine Ala
...

Importance of Neurotransmitters

Targeted Metabolomics Analysis Neurotransmitter is a chemical messenger molecule that transmits signals between synapses, and exerts its physiological effects by specifically binding to effectors or receptors on neuronal cells. Neurotransmitters are related to the occurrence and development of a variety of neurological diseases.

Application Field

Neurocardiovascular disease

Neurophysiological research, such as learning and memory, biological rhythm

Neurological diseases, such as muscle weakness, epilepsy, Parkinson's

Mental illness, such as depression, schizophrenia

Nervous system disease

Metabolic disease

Analytical Substance

Acetylcholine

Catecholamines (norepinephrine and dopamine)

Serotonin

γ-aminobutyric acid

Histamine

Importance of Fatty Acid

Targeted Metabolomics Analysis Fatty acids are the main components of cell membranes. They are divided into short-chain fatty acid (SCFA) and medium-long-chain fatty acids according to the length of the carbon chain. Short-chain fatty acids are organic fatty acids with 2-6 carbon chains. As metabolites of intestinal microbes, they can not only regulate the balance of intestinal flora, but also have the effects of anti-pathogenic microbes, anti-inflammatory, anti-tumor and regulating gene expression. Medium and long-chain fatty acids refer to fatty acids with more than 6 carbon atoms. They not only provide energy for the life activities of organisms, but also are important signal molecules that participate in the regulation of multiple biological processes such as insulin secretion and immune cells. In short, fatty acids have the functions of inhibiting bacteria and regulating the structure of intestinal flora, and are related to many diseases.

Application Field

Metabolic syndrome, lipid metabolism, insulin resistance, obesity, 2-diabetes, cardiovascular disease, liver disease

Tumor research

Inflammatory disease research

Analytical Substance

◎ Acetic acid ◎ Propionic acid ◎ Butyric acid ◎ Isobutyric acid
◎ Caproic acid ◎ Methyl caprylate ◎ Valeric acid ◎ Isovaleric acid
◎ Methyl undecanoate ◎ Methyl caproate ◎ Methyl caprate ...

Importance of Plant Hormone

Targeted Metabolomics Analysis Phytohormones are essential signaling molecules for plants to sense changes in the external environment, regulate their own growth, resist bad environments, and maintain survival. They are of great significance for regulating various growth and development processes of plants and environmental responses.

Application Field

Research on the mechanism of plant resistance to stress

Growth and development mechanism research

Plant breeding research

Analytical Substance

◎ Salicylic acid ◎ Jasmonic acid ◎ Abscisic acid ◎ Gibberellin
◎ Cytokinin ◎ Ethylene ◎ Auxin ◎ Brassinolide

Importance of Vitamins

Vitamins are a type of trace organic substances that humans and animals must obtain from food in order to maintain normal physiological functions. This type of substance is neither a raw material for body tissue nor a source of energy, but a type of regulatory substance. It plays an important role in the growth, metabolism and development of the human body. By analyzing LC-MS/MS mass spectrometry data, the absolute content of multivitamins in biological samples can be specifically detected.

Application Field

Body nutritional status assessment

Auxiliary disease diagnosis

Food nutritional value evaluation

 Animal nutrition research

Analytical Substance

◎ Vitamin A ◎ Vitamin B ◎ Vitamin C ◎ Vitamin D
◎ Vitamin E ◎ Vitamin K ...
* For Research Use Only. Not for use in diagnostic procedures.
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